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Comment
. 2019 Jan 8;116(2):353-355.
doi: 10.1073/pnas.1819412116. Epub 2019 Jan 2.

Shedding new light on the mysteries of tooth eruption

Joy M Richman  1
Affiliations
Comment

Shedding new light on the mysteries of tooth eruption

Joy M Richman. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway. (A) In the preeruptive phase, teeth are fully surrounded by a bony crypt. The enamel organ produces PTHrP and CSF1 (arrows) which feed back to the dental follicle. (B) The intraosseous phase is characterized by the spatially restricted removal of bone on the coronal side of the tooth due to signals from the dental follicle (arrows). Osteoclasts invade and resorb the bone to create an eruption pathway (ep). Cementum starts to form on the root surfaces (c). (C) First molars in the present study (1) create an eruption pathway but do not move into the occlusal plane (red X). Excess cementum forms (c), perhaps forming transient fusions with bone, preventing eruption. (D) Normally, teeth move through the eruption pathway and form an attachment to the surrounding bone via the periodontal ligament. A full deletion of Pthrp followed by restoration of expression in the enamel organ using K14-Pthrp rescues eruption (5).
See this image and copyright information in PMC

Comment on

References

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