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Review
. 2019 Feb;21(2):143-151.
doi: 10.1038/s41556-018-0242-9. Epub 2019 Jan 2.

Intergenerational and transgenerational epigenetic inheritance in animals

Marcos Francisco Perez  1 , Ben Lehner  2   3   4
Affiliations
Review

Intergenerational and transgenerational epigenetic inheritance in animals

Marcos Francisco Perez et al. Nat Cell Biol. 2019 Feb.

Abstract

Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.

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References

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