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Review
. 2019 Feb;21(2):133-142.
doi: 10.1038/s41556-018-0244-7. Epub 2019 Jan 2.

The lysosome as a cellular centre for signalling, metabolism and quality control

Rosalie E Lawrence  1   2 , Roberto Zoncu  3   4
Affiliations
Review

The lysosome as a cellular centre for signalling, metabolism and quality control

Rosalie E Lawrence et al. Nat Cell Biol. 2019 Feb.

Abstract

Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regulator mechanistic target of rapamycin complex 1 kinase is activated on lysosomes in response to nutrient and growth factor inputs. Lysosomes also enable autophagy, a 'self-eating' process essential for quality control and stress adaptation. Faulty execution of lysosomal growth and catabolic programmes drives cancer, neurodegeneration and age-related diseases.

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References

    1. Perera, R. M. & Zoncu, R. The lysosome as a regulatory hub. Annu. Rev. Cell Dev. Biol. 32, 223–253 (2016). - PubMed
    1. Settembre, C., Fraldi, A., Medina, D. L. & Ballabio, A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat. Rev. Mol. Cell Biol. 14, 283–296 (2013). - PubMed - PMC
    1. Zhao, J., Benlekbir, S. & Rubinstein, J. L. Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase. Nature 521, 241–245 (2015). - PubMed
    1. Jezegou, A. et al. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc. Natl Acad. Sci. USA 109, E3434–E3443 (2012). - PubMed
    1. Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337, 351–354 (2012). - PubMed - PMC

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