Review
doi: 10.1038/s41556-018-0196-y.
Epub 2019 Jan 2.
Non-redundant functions of EMT transcription factors
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- PMID: 30602760
- DOI: 10.1038/s41556-018-0196-y
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Review
Non-redundant functions of EMT transcription factors
Nat Cell Biol.
2019 Jan.
Abstract
Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
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