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Review
. 2019 Jan;21(1):85-93.
doi: 10.1038/s41556-018-0217-x. Epub 2019 Jan 2.

Metabolism as a guiding force for immunity

Jonathan Jung  1   2 , Hu Zeng  3   4 , Tiffany Horng  5   6
Affiliations
Review

Metabolism as a guiding force for immunity

Jonathan Jung et al. Nat Cell Biol. 2019 Jan.

Abstract

Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.

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