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Review
. 2019 Jan;21(1):9-17.
doi: 10.1038/s41556-018-0250-9. Epub 2019 Jan 2.

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu  1   2 , Lorena Martin-Jaular  1 , Grégory Lavieu  1 , Clotilde Théry  3
Affiliations
Review

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al. Nat Cell Biol. 2019 Jan.

Abstract

The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ill-defined. Here, we discuss the current knowledge on the specificities of exosomes and other types of extracellular vesicles, and their roles as important agents of cell-to-cell communication.

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