Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun;18(2):253-259.
doi: 10.4314/ahs.v18i2.8.

Quinine inhibits ovulation and produces oxidative stress in the ovary of cyclic Sprague-Dawley rats

Stella Chinwe Gbotolorun  1 , Oghenevwakpeje Inikori  1 , Olawande Damilola Bamisi  1 , Abraham Adewale Adepoju Osinubi  1 , Abayomi Olugbenga Okanlawon  1
Affiliations

Quinine inhibits ovulation and produces oxidative stress in the ovary of cyclic Sprague-Dawley rats

Stella Chinwe Gbotolorun et al. Afr Health Sci. 2018 Jun.

Abstract

Background: Quinine has been reported to possess anti-spermatogenic activities.

Objectives: This study was carried out to determine the effect of quinine on ovarian function in Sprague-Dawley rats.

Methods: Twenty rats with regular 4-days oestrous cycle divided into 4 groups (N=5) were used. Group I received quinine at 30 mg/kg body weight by gavage for 28 days after which they were sacrificed. The ovaries were excised for biochemical oxidation of glutathione peroxidase (GSH), superoxide dismutase (SOD), catalase and malondialdehyde (MDA). Group II received single dose quinine at 30 mg/kg body weight at 0900 hrs on day of proestrus. Blood was obtained at 1800 hrs for hormonal assay of FSH and LH. The animals were sacrificed the next morning on estrus: oviducts were examined for ova count. Groups III and IV served as controls.

Results: Quinine treated rats recorded zero number of ova compared to control. Serum concentration of LH reduced significantly in the quinine treated group compared to the control. Furthermore, quinine significantly decreased the oxidant status of GSH, SOD and catalase and significantly increased MDA levels in the ovary compared to the control group.

Conclusion: Quinine completely blocks ovulation, suppresses LH surge, and produces oxidative stress in the ovary.

Keywords: LH; Quinine; ovary; ovulation; oxidative stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. WHO, author. 19th World Health Organization Model List of Essential Medicines: April 2015. Geneva: WHO; 2015.
    1. Ogutu BR, Nzila AM, Ochong E, Mithwani S, Wamola B, Olola CHO, et al. The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children. Trop Med Int Health. 2005;5:484–488. PubMed. - PubMed
    1. Woodfield R, Goodyear-Smith F, Arroll B. N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg. Br J Gen Pract. 2005;55:181–185. - PMC - PubMed
    1. Descamps-Latscha B, Lunel-Fabiani F, Kara-Binis A, Druilhe P. Generation of reactive oxygen species in whole blood from patients with acute malaria. Parasitol Immunol. 1987;9:275–279. PubMed. - PubMed
    1. Stoker R, Hunt NH, Clark IA, Weidemann MJ. Production of luminal-reactive oxygen radicals during Plasmodium vinckei infection. Infect Immun. 1984;45:708–712. PubMed. - PMC - PubMed

MeSH terms

LinkOut - more resources