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Meta-Analysis
. 2018 Sep;18(3):689-696.
doi: 10.4314/ahs.v18i3.27.

A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis

Tianbiao Zhou  1 , Hongyan Li  2 , Weiji Xie  1 , Zhijun Lin  1
Affiliations
Meta-Analysis

A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis

Tianbiao Zhou et al. Afr Health Sci. 2018 Sep.

Abstract

Background and objectives: The purpose of this study was to compare the effects of phosphate binders lanthanum carbonate (LC) versus sevelamer hydrochloride (SH) in end-stage renal disease (ESRD) patients undergoing hemodialysis.

Methods: Studies including randomized controlled trials (RCTs) comparing phosphate binders lanthanum carbonate versus sevelamer hydrochloride, in ESRD patients undergoing hemodialysis, were identified using a pre-defined search strategy. Phosphate, calcium, calcium-phosphorus product, intact parathyroid hormone, alkaline phosphatase, total cholesterol, and triglyceride were extracted and compared by RevMan 5.1 (The Cochrane Collaboration, Oxford, UK).

Results: Six studies were identified. Meta-analysis showed that SH treatment reduced levels of phosphate, intact parathyroid hormone, and total serum alkaline phosphatase (ALP) when compared with LC treatment. Furthermore, patients on SH treatment tended to have reduced calcium levels, calcium-phosphorus product, total cholesterol, and triglyceride when compared to patients treated with LC, but there was no statistical difference.

Conclusion: SH treatment of patients with ESRD is more effective compared to LC treatment. However, more well-designed random control trails are required for confirmation.

Keywords: End-stage renal disease; hemodialysis; lanthanum carbonate (LC); meta-analysis; phosphate binders; sevelamer hydrochloride (SH).

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Figures

Figure 1
Figure 1
Phosphate levels between the SH-treated and LC-treated groups.
Figure 2
Figure 2
Calcium levels between SH group and LC group
Figure 3
Figure 3
Calcium-phosphorus product between the SH and LC groups
Figure 4
Figure 4
Intact parathyroid hormone levels between SH and LC groups
Figure 5
Figure 5
Alkaline phosphatase levels between the SH and LC groups
Figure 6
Figure 6
Total cholesterol levels between the SH and LC groups.
Figure 7
Figure 7
Triglyceride levels between the SH and LC groups.
See this image and copyright information in PMC

References

    1. Wang Z, Shi W, Liang X, Wang W, Liang J. Association of interleukin 17 / angiotensin II with refractory hypertension risk in hemodialysis patients. Afr Health Sci. 2016;16(3):766–771. - PMC - PubMed
    1. Ye JJ, Zhou TB, Zhang YF, Wang Q, Su YY, Tang JM, Li HY. Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease. Afr Health Sci. 2016;16(2):462–467. - PMC - PubMed
    1. Adrian T, Hornum M, Eriksson F, Hansen JM, Pilely K, Garred P, Feldt-Rasmussen B. Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study. Nephrol Dial Transplant. 2018 - PubMed
    1. Ong CY, Low SG, Vasanwala FF, Fook-Chong SM, Kaushik M, Low LL. Incidence and mortality rates of varicella among end stage renal disease (ESRD) patients in Singapore General Hospital, a 12-year review. BMC Infect Dis. 2018;18(1):118. - PMC - PubMed
    1. Calvo MS, Uribarri J. Contributions to total phosphorus intake: all sources considered. Semin Dial. 2013;26(1):54–61. - PubMed

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