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Review
. 2018 Dec 27:12:36.
doi: 10.1186/s13036-018-0133-4. eCollection 2018.

Tissue engineering strategies for the induction of angiogenesis using biomaterials

Shirin Saberianpour  1   2 , Morteza Heidarzadeh  1 , Mohammad Hossein Geranmayeh  3 , Hossein Hosseinkhani  4 , Reza Rahbarghazi #  1   5 , Mohammad Nouri #  2   1   5
Affiliations
Review

Tissue engineering strategies for the induction of angiogenesis using biomaterials

Shirin Saberianpour et al. J Biol Eng. .

Abstract

Angiogenesis is touted as a fundamental procedure in the regeneration and restoration of different tissues. The induction of de novo blood vessels seems to be vital to yield a successful cell transplantation rate loaded on various scaffolds. Scaffolds are natural or artificial substances that are considered as one of the means for delivering, aligning, maintaining cell connection in a favor of angiogenesis. In addition to the potential role of distinct scaffold type on vascularization, the application of some strategies such as genetic manipulation, and conjugation of pro-angiogenic factors could intensify angiogenesis potential. In the current review, we focused on the status of numerous scaffolds applicable in the field of vascular biology. Also, different strategies and priming approaches useful for the induction of pro-angiogenic signaling pathways were highlighted.

Keywords: Cell source; Delivery methods; Genetic and proteomic manipulation; Scaffolds; Vascular regeneration.

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Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Various cell sources used at the current for vascular regeneration or induction of Angiogenesis. Many cell sources are applicable to regenerate various tissues by affecting angiogenesis and blood support
Fig. 2
Fig. 2
miRNA delivery systems in the field of tissue engineering
Fig. 3
Fig. 3
Effect of different of biomaterials on intracellular angiogenesis signaling pathways. VEGFR-2, E-cadherin and CD44 could be initiated after juxtaposition to different scaffolds. Signaling pathways effectors such as Akt and Raf and Erk are stimulated during angiogenesis potential. HA: Hyaluronic acid
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References

    1. Rana D, Zreiqat H, Benkirane-Jessel N, Ramakrishna S, Ramalingam M. Development of decellularized scaffolds for stem cell-driven tissue engineering. J Tissue Eng Regen Med. 2017;11(4):942–965. doi: 10.1002/term.2061. - DOI - PubMed
    1. Cosson S, Otte EA, Hezaveh H, Cooper-White JJ. Concise review: tailoring bioengineered scaffolds for stem cell applications in tissue engineering and regenerative medicine. Stem Cells Transl Med. 2015;4(2):156–164. doi: 10.5966/sctm.2014-0203. - DOI - PMC - PubMed
    1. Rezaie J, Mehranjani MS, Rahbarghazi R, Shariatzadeh MA. Angiogenic and Restorative Abilities of Human Mesenchymal Stem Cells Were Reduced Following Treatment With Serum From Diabetes Mellitus Type 2 Patients. J Cell Biochem. 2018;119(1):524–535. doi: 10.1002/jcb.26211. - DOI - PubMed
    1. Hassanpour M, Cheraghi O, Siavashi V, Rahbarghazi R, Nouri M. A reversal of age-dependent proliferative capacity of endothelial progenitor cells from different species origin in in vitro condition. J Cardiovasc Thor Res. 2016;8(3):102–106. doi: 10.15171/jcvtr.2016.22. - DOI - PMC - PubMed
    1. Mueller SB, Kontos CD. Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling. J Clin Invest. 2016;126(9):3188–3191. doi: 10.1172/jci89963. - DOI - PMC - PubMed

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