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Case Reports
. 2018 Dec;9(6):1207-1212.
doi: 10.21037/jgo.2018.07.06.

Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis

Maia Belhassine  1 , Eugenia Papakrivopoulou  2 , Christian Venet  3 , Carole Mestdagh  4 , Marc Schroeven  1
Affiliations
Case Reports

Gastric adenocarcinoma revealed by atypical pulmonary lymphangitic carcinomatosis

Maia Belhassine et al. J Gastrointest Oncol. 2018 Dec.

Abstract

Pulmonary lymphangitic carcinomatosis (PLC) is a well-known form of tumour metastasis to the pulmonary lymphatic system or to the adjacent interstitial tissue resulting in thickening of the bronchovascular bundle and septa. Another type of tumour metastasis to the lung involves the pulmonary vascular system and is known as pulmonary tumour thrombotic microangiopathy (PTTM). In this article, we will describe the unusual case of a young Chinese woman with gastric adenocarcinoma revealed by atypical radiographic lesions consistent with both PLC and PTTM. We will discuss the existing evidence and hypotheses about the pathophysiology of both conditions.

Keywords: Gastric adenocarcinoma; pulmonary hypertension; pulmonary lymphangitic carcinomatosis (PLC); pulmonary tumor thrombotic microangiopathy; vascular endothelial growth factor (VEGF).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
HRCT transverse sections. The image shows the “crazy paving” pattern (arrows) resulting from ground glass opacities (asterisk) and interlobular septa thickening (arrowhead). HRCT, high resolution computed tomography.
Figure 2
Figure 2
CT abdomen. Enlargement of gastric antrum (asterix) and thickening of the gastric mucosa (arrow).
See this image and copyright information in PMC

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