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Editorial
. 2017 Mar 30;8(2):137-138.
doi: 10.1007/s13340-017-0317-z. eCollection 2017 Jun.

Role of GIP receptor signaling in β-cell survival

Norio Harada  1 , Nobuya Inagaki  1
Affiliations
Editorial

Role of GIP receptor signaling in β-cell survival

Norio Harada et al. Diabetol Int. .
No abstract available

Keywords: Extracellular signal-regulated kinase; GIP receptor; TCF1; β-Cell survival.

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Figures

Fig. 1
Fig. 1
Molecular mechanism of GIP- and GLP-1-induced insulin secretion and β-cell survival. GIP and GLP-1 potentiate glucose-dependent insulin secretion through PKA and Epac2 (black arrows). GLP-1 is well known to be associated with β-cell survival (as it exerts an antiapototic effect), reduction of ER stress, and β-cell maturation and differentiation (blue arrows). Campbell et al. have shown a new pathway for GIP-induced β-cell survival (red arrows)
See this image and copyright information in PMC

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