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. 2018 Dec;4(4):232-239.
doi: 10.5114/ceh.2018.80124. Epub 2018 Dec 3.

Health-related quality of life in liver cirrhosis patients using SF-36 and CLDQ questionnaires

K Janani  1 , Mayank Jain  1 , Joy Vargese  1 , Vijaya Srinivasan  1 , Kavya Harika  1 , Tom Michael  1 , Jayanthi Venkataraman  1
Affiliations

Health-related quality of life in liver cirrhosis patients using SF-36 and CLDQ questionnaires

K Janani et al. Clin Exp Hepatol. 2018 Dec.

Abstract

Aim of the study: To determine the factors that are likely to influence the domains of health-related quality of life (HRQOL) using SF-36 and CLDQ questionnaires in patients with liver cirrhosis.

Material and methods: Patients with liver cirrhosis were compared with age- and gender-matched healthy controls for physical and mental components of the SF-36 score. Effects of age, co-morbidity, namely diabetes, severity of liver disease and complications of liver cirrhosis on HRQOL using self-administered or by direct interview SF-36 and CLDQ questionnaires were studied. Statistical analysis: chi square test, ANOVA, Kruskal-Wallis test and stepwise linear regression analysis. A p value of < 0.05 was considered significant.

Results: Regarding SF-36 score, except for bodily pain, 149 patients had significantly low individual and composite domain scores (p value < 0.0001) compared to age/gender-matched controls. Patients below 45 years, the majority of whom belonged to Child-Turcotte-Pugh (CTP) class C with a high Model of End-Stage Liver Disease (MELD) and higher rates of complication had low SF-36 for bodily pain (KW p < 0.005) and those above 55 years for physical function (p < 0.05). Both the physical components had a major impact on mental composite score (MCS) (KW p < 0.05). The overall CLDQ score was also low in patients below 45 years old (p < 0.05). Diabetes with or without other co-morbid conditions had no effect on SF-36 or CLDQ scores, while non-diabetic co-morbid conditions did on physical domains (physical function, bodily pain and role physical) and the physical component score of SF-36 (KW p < 0.01 to < 0.0001). In linear regression, MELD had a direct and significant association with overall PCS, MCS and CLDQ.

Conclusions: Age below 45 years, higher MELD and CTP score with the presence of ascites and hepatic encephalopathy affect the overall CLDQ scores.

Keywords: cirrhosis liver; quality of life.

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Figures

Fig. 1
Fig. 1
Comparison of median SF-36 scores among cases and controls
See this image and copyright information in PMC

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