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Clinical Trial
. 1988 Dec;50(6):864-71.
doi: 10.1016/s0015-0282(16)60363-1.

Danazol but not gonadotropin-releasing hormone agonists suppresses autoantibodies in endometriosis

A el-Roeiy  1 , W P Dmowski, N Gleicher, E Radwanska, L Harlow, Z Binor, I Tummon, R G Rawlins
Affiliations
Free article
Clinical Trial

Danazol but not gonadotropin-releasing hormone agonists suppresses autoantibodies in endometriosis

A el-Roeiy et al. Fertil Steril. 1988 Dec.
Free article

Abstract

The effect of treatment with danazol (n = 10) or gonadotropin-releasing hormone agonists (GnRH-a) (n = 10) on autoantibody (AA) production (IgG, IgM and, IgA to 6 phospholipids, 5 histones, and 4 polynucleotides) in endometriosis was evaluated blindly in a longitudinal, prospective, randomized study. Clinical improvement, ovarian suppression, and resolution of endometriosis were comparable in both groups. Approximately 50% of patients had significant AA abnormalities initially. During treatment with danazol but not GnRH-a, AA gradually decreased in concentration and in number/patient. Total immunoglobulin levels (IgG, IgM, and IgA) also decreased only in the danazol group. This study indicates that danazol, but not GnRH-a, lowers abnormal AA associated with endometriosis.

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Comment in

  • Endometriosis and autoantibodies.
    Redwine DB. Redwine DB. Fertil Steril. 1989 Jun;51(6):1068-9. doi: 10.1016/s0015-0282(16)60753-7. Fertil Steril. 1989. PMID: 2656308 No abstract available.

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