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. 2019 Feb;145(2):457-462.
doi: 10.1007/s00432-018-2793-3. Epub 2019 Jan 2.

Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas

Lars-Christian Horn  1 , Anne Katrin Höhn  2 , Bettina Hentschel  3 , Uta Fischer  2   4 , Karl Bilek  4 , Christine E Brambs  5
Affiliations

Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas

Lars-Christian Horn et al. J Cancer Res Clin Oncol. 2019 Feb.

Abstract

Purpose: Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix.

Methods: Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using the different degree of keratinization, categorizing the tumors in G1, G2 and G3 (conventional tumor grade).

Results: 45.1% presented with well-differentiated tumors (G1), 29.2% with moderate (G2) and 25.8% with poor differentiation (G3). Tumor grade significantly correlated with decreased recurrence-free and overall survival. However, detailed analyses between G1- and G2-tumors failed to show any correlation with either recurrence-free or overall survival. G1- and G2-tumors were therefore merged into low-grade tumors and were compared to the high-grade group (G3-tumors). This binary conventional grading system showed an improved 5-years recurrence-free (low-grade: 90.2% vs. high-grade: 71.6%; p = 0.001) and overall survival rates (low-grade: 89.9% vs. high-grade: 71.1%; p = 0.001) for low-grade tumors. On multivariate analysis adjusted for lymph node metastasis, high-grade tumors represented a hazard ratio of 2.4 (95% CI 1.3-4.7) for reduced recurrence-free and 2.4 (95% CI 1.2-4.6) for overall survival. High-grade tumors showed a significantly higher risk for pelvic lymph node involvement [OR 2.7 (95% CI 1.4-5.5); p = 0.003]. The traditional three-tiered grading system failed to predict pelvic lymph node metastases.

Conclusion: A binary grading model for the conventional tumor grade (based on the degree of keratinization) in SCC of the uterine cervix may allow a better prognostic discrimination than the traditionally used three-tiered system.

Keywords: Cancer; Cervix; Grading; Histopathology; Prognosis; Squamous cell; Survival; Treatment.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Kaplan–Meier curves for prognostic impact of conventional tumor grading in squamous cell carcinoma of the uterine cervix using a 3-tiered grading system (please see text). a Recurrence-free survival. b Overall survival
Fig. 2
Fig. 2
Kaplan–Meier curves for the prognostic impact of conventional tumor grading in squamous cell carcinoma of the uterine cervix using a 2-tiered grading system (please see text). a Recurrence-free survival. b Overall survival
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