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Review
. 2018 Oct;41(4):247-255.

Evidence-based renewal of the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons

Andrea Antinori  1 , Antonio Di Biagio  2 , Simone Marcotullio  3 , Loredana Sarmati  4 , Massimo Andreoni  4 , Gioacchino Angarano  5 , Antonio Chirianni  6 , Antonella d'Arminio Monforte  7 , Giovanni Di Perri  8 , Massimo Galli  9 , Nicola Gianotti  10 , Enrico Girardi  1 , Andrea Gori  11 , Cristina Mussini  12 , Carlo-Federico Perno  13 , Adriano Lazzarin  14
Affiliations
  • PMID: 30604833
Free article
Review

Evidence-based renewal of the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons

Andrea Antinori et al. New Microbiol. 2018 Oct.
Free article

Abstract

The Italian Society for Infectious and Tropical Diseases (SIMIT) in collaboration with the Technical Health Committee (Sections L and M) of the Italian Ministry of Health have supported the renewal of the recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2017 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. New recommendations were released framing the clinical questions the use of antiretrovirals according to the Patient Intervention Comparator Outcome (PICO) methodology and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Diagnostic tools for immunological and virological monitoring, when to start, what to start, optimization and therapeutic failure were updated in order to include the recommendation obtained with these newly developed methods. For a complete review of clinical and therapeutic relevant topics we refer the reader to the extended version of the Guidelines.

Keywords: Antiretroviral therapy; HIV; Treatment guidelines.

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