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Comment
. 2019 Jan 2;27(1):1-3.
doi: 10.1016/j.str.2018.12.009.

The Structure of HPK1 Kinase Domain: To Boldly Go Where No Immuno-Oncology Drugs Have Gone Before

Sansana Sawasdikosol  1 , Steven Burakoff  2
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The Structure of HPK1 Kinase Domain: To Boldly Go Where No Immuno-Oncology Drugs Have Gone Before

Sansana Sawasdikosol et al. Structure. .
Free article

Abstract

In this issue of Structure, Wu et al. (2018) report several apo and small-molecule inhibitor-bound structures of the kinase domain of hematopoietic progenitor kinase 1, a ser/thr kinase that functions as an inhibitor of T cell activation. The studies reveal that the HPK1 kinase domain exists as a domain-swapped dimer.

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