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. 2019;67(1):41-46.
doi: 10.1248/cpb.c18-00645.

Four New Compounds Isolated from the Aerial Part of Belamcanda chinensis (L.) and Their Effect on Vascular Smooth Muscle Cell (VSMC) Proliferation

Do Thi Ha  1 , Bui Thi Binh  1   2 , Nguyen Thi Thu  1 , Nguyen Thi Bich Thu  1 , Pham Ha Thanh Tung  3 , Won Keun Oh  3
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Free article

Four New Compounds Isolated from the Aerial Part of Belamcanda chinensis (L.) and Their Effect on Vascular Smooth Muscle Cell (VSMC) Proliferation

Do Thi Ha et al. Chem Pharm Bull (Tokyo). 2019.
Free article

Abstract

Bio-guided fractionation of the 70% ethanol extract of Belamcanda chinensis (L.) DC. revealed four new compounds, including 6″-O-acetylembinin (5), 3″-O-acetylembinin (6), irigenin 3'-O-β-glucopyranoside (8), and 2'-acetyl-1,3-O-diferuloylsucrose (9), along with five known compounds (1-4, 7). Their chemical structures were determined using extensive NMR data, mass spectroscopy, and comparison with published literature. Among the isolates, compounds 1 and 4-7 achieved good regulation of the growth and proliferation of vascular smooth muscle cells.

Keywords: 2′-O-acetyl-1,3-O-diferuloylsucrose; Belamcanda chinensis; Iridaceae; flavonoid glycoside; vascular smooth muscle cell (VSMC) proliferation.

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