Comment

. 2019 Feb;29(2):93-94.

doi: 10.1038/s41422-018-0126-3.

Probiotic fengycins dis(Agr)ee with Staphylococcus aureus colonization

Lawton K Chung¹, Manuela Raffatellu^{2

3

4}

Affiliations

¹ Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
² Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA. manuelar@ucsd.edu.
³ Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA, 92093, USA. manuelar@ucsd.edu.
⁴ Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA. manuelar@ucsd.edu.

PMID: 30607015
PMCID: PMC6355905
DOI: 10.1038/s41422-018-0126-3

Comment

Probiotic fengycins dis(Agr)ee with Staphylococcus aureus colonization

Lawton K Chung et al. Cell Res. 2019 Feb.

. 2019 Feb;29(2):93-94.

doi: 10.1038/s41422-018-0126-3.

Authors

Lawton K Chung¹, Manuela Raffatellu^{2

3

4}

Affiliations

¹ Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
² Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA. manuelar@ucsd.edu.
³ Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA, 92093, USA. manuelar@ucsd.edu.
⁴ Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA. manuelar@ucsd.edu.

PMID: 30607015
PMCID: PMC6355905
DOI: 10.1038/s41422-018-0126-3

No abstract available

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Figures

**Fig. 1**
*Bacillus* eliminates intestinal *Staphylococcus aureus* colonization. a Fengycins produced by wild-type *B. subtilis* compete with Agr autoinducing peptides (AIPs) and block AgrC-dependent quorum sensing in *S. aureus*, thus reducing the expression of virulence factors and eliminating intestinal colonization by the pathogen. b A *B. subtilis* mutant defective in fengycin synthesis (Δ*fenA*) fails to inhibit *S. aureus* quorum sensing, virulence factor expression, and colonization

See this image and copyright information in PMC

Comment on

Pathogen elimination by probiotic Bacillus via signalling interference.
Piewngam P, Zheng Y, Nguyen TH, Dickey SW, Joo HS, Villaruz AE, Glose KA, Fisher EL, Hunt RL, Li B, Chiou J, Pharkjaksu S, Khongthong S, Cheung GYC, Kiratisin P, Otto M. Piewngam P, et al. Nature. 2018 Oct;562(7728):532-537. doi: 10.1038/s41586-018-0616-y. Epub 2018 Oct 10. Nature. 2018. PMID: 30305736 Free PMC article.

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Probiotic fengycins dis(Agr)ee with Staphylococcus aureus colonization

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