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. 2018 Dec;25(6):e610-e614.
doi: 10.3747/co.25.4093. Epub 2018 Dec 1.

Does the presence of emphysema increase the risk of radiation pneumonitis in lung cancer patients?

G Kasymjanova  1 , R T Jagoe  1 , C Pepe  1 , L Sakr  1 , V Cohen  1 , D Small  1 , T M Muanza  2 , J S Agulnik  1
Affiliations

Does the presence of emphysema increase the risk of radiation pneumonitis in lung cancer patients?

G Kasymjanova et al. Curr Oncol. 2018 Dec.

Abstract

Introduction: Radiotherapy (rt) plays an important role in the treatment of lung cancer. One of the most common comorbidities in patients with lung cancer is pulmonary emphysema. The literature offers conflicting data about whether emphysema increases the occurrence and severity of radiation pneumonitis (rp). As a result, whether high doses of rt (with curative intent) should be avoided in patients with emphysema is still unclear.

Objective: We measured the documented incidence of rp in patients with and without emphysema who received curative radiation treatment.

Methods: This retrospective cohort study considered patients in the lung cancer clinical database of the Peter Brojde Lung Cancer Centre. Data from the database has been used previously for research studies, including a recent publication about emphysema grading, based on the percentage of lung occupied by emphysema on computed tomography (ct) imaging.

Results: Using previously published methods, chest ct imaging for 498 patients with lung cancer was scored for the presence of emphysema. The analysis considered 114 patients who received at least 30 Gy radiation. Of those 114 patients, 64 (56%) had emphysema, with approximately 23% having severe or very severe disease. The incidence of rp was 34.4% in patients with emphysema (n = 22) and 32.0% in patients with no emphysema (n = 16, p = 0.48). No difference in the incidence of rp was evident between patients with various grades of emphysema (p = 0.96). Similarly, no difference in the incidence of rp was evident between the two treatment protocols-that is, definitive rt 17 (37%) and combined chemotherapy-rt 21 (31%, p = 0.5).

Conclusions: In our cohort, the presence of emphysema on chest ct imaging was not associated with an increased risk of rp. That finding suggests that patients with lung cancer and emphysema should be offered rt when clinically indicated. However, further prospective studies will be needed for confirmation.

Keywords: Lung cancer; emphysema; radiation pneumonitis.

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Conflict of interest statement

CONFLICT OF INTEREST DISCLOSURES We have read and understood Current Oncology’s policy on disclosing conflicts of interest, and we declare that we have none. We have full control of all primary data and agree to allow review of our data if requested.

Figures

FIGURE 1
FIGURE 1
Lung cancer patients enrolled in the analysis. aEmphysema on computed tomography imaging (CT). RP = radiation pneumonitis.
FIGURE 2
FIGURE 2
Rate of emphysema in patients with lung cancer who did or did not receive radiotherapy.
FIGURE 3
FIGURE 3
Rate of radiation pneumonitis in patients with lung cancer by grade of emphysema.
See this image and copyright information in PMC

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