A Review of Herbal Therapy in Multiple Sclerosis

doi:10.15171/apb.2018.066

Review

. 2018 Nov;8(4):575-590.

doi: 10.15171/apb.2018.066. Epub 2018 Nov 29.

A Review of Herbal Therapy in Multiple Sclerosis

Sina Mojaverrostami¹, Maryam Nazm Bojnordi^{2

3}, Maryam Ghasemi-Kasman⁴, Mohammad Ali Ebrahimzadeh⁵, Hatef Ghasemi Hamidabadi^{2

6}

Affiliations

¹ Young Researchers and Elite Club, Behshahr Branch, Islamic Azad University, Behshahr, Iran.
² Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Cellular and Molecular Research Center, Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁵ Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
⁶ Immunogenetic Research Center, Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

PMID: 30607330
PMCID: PMC6311642
DOI: 10.15171/apb.2018.066

Review

A Review of Herbal Therapy in Multiple Sclerosis

Sina Mojaverrostami et al. Adv Pharm Bull. 2018 Nov.

. 2018 Nov;8(4):575-590.

doi: 10.15171/apb.2018.066. Epub 2018 Nov 29.

Authors

Sina Mojaverrostami¹, Maryam Nazm Bojnordi^{2

3}, Maryam Ghasemi-Kasman⁴, Mohammad Ali Ebrahimzadeh⁵, Hatef Ghasemi Hamidabadi^{2

6}

Affiliations

¹ Young Researchers and Elite Club, Behshahr Branch, Islamic Azad University, Behshahr, Iran.
² Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Cellular and Molecular Research Center, Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁵ Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
⁶ Immunogenetic Research Center, Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

PMID: 30607330
PMCID: PMC6311642
DOI: 10.15171/apb.2018.066

Abstract

Multiple sclerosis is a complex autoimmune disorder which characterized by demyelination and axonal loss in the central nervous system (CNS). Several evidences indicate that some new drugs and stem cell therapy have opened a new horizon for multiple sclerosis treatment, but current therapies are partially effective or not safe in the long term. Recently, herbal therapies represent a promising therapeutic approach for multiple sclerosis disease. Here, we consider the potential benefits of some herbal compounds on different aspects of multiple sclerosis disease. The medicinal plants and their derivatives; Ginkgo biloba, Zingiber officinale, Curcuma longa, Hypericum perforatum, Valeriana officinalis, Vaccinium macrocarpon, Nigella sativa,Piper methysticum, Crocus sativus, Panax ginseng, Boswellia papyrifera, Vitis vinifera, Gastrodia elata, Camellia sinensis, Oenothera biennis, MS14 and Cannabis sativa have been informed to have several therapeutic effects in MS patients.

Keywords: Demyelination; Herbal therapy; Inflammation; Multiple sclerosis; Remyelination.

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References

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1. Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH. et al. Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol. 2010;225(1):18–23. doi: 10.1016/j.expneurol.2009.12.020. - DOI - PubMed
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[1] Camina-Tato M, Fernandez M, Morcillo-Suarez C, Navarro A, Julia E, Edo MC. et al. Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis. J Neuroimmunol. 2010;222(1-2):70–5. doi: 10.1016/j.jneuroim.2010.03.003. - DOI - PubMed

[2] Camina-Tato M, Fernandez M, Morcillo-Suarez C, Navarro A, Julia E, Edo MC. et al. Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis. J Neuroimmunol. 2010;222(1-2):70–5. doi: 10.1016/j.jneuroim.2010.03.003. - DOI - PubMed

[3] Hasan KM, Walimuni IS, Abid H, Datta S, Wolinsky JS, Narayana PA. Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS. J Neurol Sci. 2012;313(1-2):99–109. doi: 10.1016/j.jns.2011.09.015. - DOI - PMC - PubMed

[4] Hasan KM, Walimuni IS, Abid H, Datta S, Wolinsky JS, Narayana PA. Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS. J Neurol Sci. 2012;313(1-2):99–109. doi: 10.1016/j.jns.2011.09.015. - DOI - PMC - PubMed

[5] Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: From biology to therapy. Nat Rev Neurosci. 2008;9(11):839–55. doi: 10.1038/nrn2480. - DOI - PubMed

[6] Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: From biology to therapy. Nat Rev Neurosci. 2008;9(11):839–55. doi: 10.1038/nrn2480. - DOI - PubMed

[7] Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH. et al. Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol. 2010;225(1):18–23. doi: 10.1016/j.expneurol.2009.12.020. - DOI - PubMed

[8] Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH. et al. Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol. 2010;225(1):18–23. doi: 10.1016/j.expneurol.2009.12.020. - DOI - PubMed

[9] Franklin RJ, Kotter MR. The biology of CNS remyelination: The key to therapeutic advances. J Neurol. 2008;255 Suppl 1:19–25. doi: 10.1007/s00415-008-1004-6. - DOI - PubMed

[10] Franklin RJ, Kotter MR. The biology of CNS remyelination: The key to therapeutic advances. J Neurol. 2008;255 Suppl 1:19–25. doi: 10.1007/s00415-008-1004-6. - DOI - PubMed

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A Review of Herbal Therapy in Multiple Sclerosis

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A Review of Herbal Therapy in Multiple Sclerosis

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