Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov 30:7:150.
doi: 10.4103/abr.abr_149_18. eCollection 2018.

Is Vitamin D Supplementation Effective in Prevention of Recurrent Urinary Tract Infections in the Pediatrics? A Randomized Triple-Masked Controlled Trial

Alireza Merrikhi  1 , Elahe Ziaei  1 , Armindokht Shahsanai  1 , Roya Kelishadi  1 , Asieh Maghami-Mehr  2
Affiliations

Is Vitamin D Supplementation Effective in Prevention of Recurrent Urinary Tract Infections in the Pediatrics? A Randomized Triple-Masked Controlled Trial

Alireza Merrikhi et al. Adv Biomed Res. .

Abstract

Background: This study aimed to evaluate the impact of Vitamin D supplementation on prevention of recurrent urinary tract infections (UTIs) in the pediatrics.

Materials and methods: This randomized, triple-blind, placebo-controlled clinical trial was conducted in 2014 among 68 children and adolescents with recurrent UTI. They were randomly assigned to two groups, receiving either Vitamin D (1000 IU/daily) or placebo for 6 months. The serum concentration of Vitamin D before and after the study and the frequency of UTI during the study were recorded.

Results: Overall 33 patients in the group of receiving Vitamin D and 32 in the placebo group completed the trial. The mean serum level of Vitamin D had a significant increase in the intervention group (15.80 ± 8.7 vs. 20.56 ± 8.30 ng/mL, P < 0.001) and significant decrease in the placebo group (20.43 ± 13.28 vs. 17.43 ± 9.99 ng/mL, P = 0.041). During the trial, the frequency of UTI was not significantly different between the two groups studied (P = 0.72). Both before and after the trial, the frequency of Vitamin D deficiency, insufficiency, and adequacy was not significantly different within and between groups (P > 0.05).

Conclusion: The findings of this trial revealed that Vitamin D supplementation with the mentioned dose have not significant impact on preventing recurrent UTI. Future studies with higher doses of Vitamin D and longer follow-up are suggested.

Keywords: Children; Vitamin D; prevention; urinary tract infection.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Consort diagram of the study
Figure 2
Figure 2
The mean of vitamin changes in terms of the urinary tract infection frequencies in the two groups
See this image and copyright information in PMC

References

    1. Awais M, Rehman A, Baloch NU, Khan F, Khan N. Evaluation and management of recurrent urinary tract infections in children: State of the art. Expert Rev Anti Infect Ther. 2015;13:209–31. - PubMed
    1. Frankul FA, Tawaige ZH, AL-Janabi AA. Urinary tract infections in febrile children. J Fac Med (Baghdad) 2003;45:41–50.
    1. Salo J, Ikäheimo R, Tapiainen T, Uhari M. Childhood urinary tract infections as a cause of chronic kidney disease. Pediatrics. 2011;128:840–7. - PubMed
    1. Williams G, Craig JC. Long-term antibiotics for preventing recurrent urinary tract infection in children? Cochrane Database Syst Rev. 2011 Mar;16(3):CD001534. doi: 10.1002/14651858.pub3. - PubMed
    1. Nickavar A, Sotoudeh K. Treatment and prophylaxis in pediatric urinary tract infection. Int J Prev Med. 2011;2:4–9. - PMC - PubMed