Data-Augmented Modeling of Intracranial Pressure
- PMID: 30607645
- PMCID: PMC7155952
- DOI: 10.1007/s10439-018-02191-z
Data-Augmented Modeling of Intracranial Pressure
Abstract
Precise management of patients with cerebral diseases often requires intracranial pressure (ICP) monitoring, which is highly invasive and requires a specialized ICU setting. The ability to noninvasively estimate ICP is highly compelling as an alternative to, or screening for, invasive ICP measurement. Most existing approaches for noninvasive ICP estimation aim to build a regression function that maps noninvasive measurements to an ICP estimate using statistical learning techniques. These data-based approaches have met limited success, likely because the amount of training data needed is onerous for this complex applications. In this work, we discuss an alternative strategy that aims to better utilize noninvasive measurement data by leveraging mechanistic understanding of physiology. Specifically, we developed a Bayesian framework that combines a multiscale model of intracranial physiology with noninvasive measurements of cerebral blood flow using transcranial Doppler. Virtual experiments with synthetic data are conducted to verify and analyze the proposed framework. A preliminary clinical application study on two patients is also performed in which we demonstrate the ability of this method to improve ICP prediction.
Keywords: Cerebrovascular dynamics; Data assimilation; Patient-specific modeling; Transcranial Doppler.
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References
-
- Andrews PJ, Citerio G, Longhi L, Polderman K, Sahuquillo J, Vajkoczy P, Care N-I, E. M. N. S. of the European Society of Intensive Care Medicine et al. NICEM consensus on neurological monitoring in acute neurological disease. Intensive care medicine 34:1362–1370, 2008. - PubMed
-
- Asiedu DP, Lee K-J, Mills G, and Kaufmann EE. A review of non-invasive methods of monitoring intracranial pressure. Journal of Neurology Research 4:1–6, 2014.
-
- Bertoglio C, Moireau P, and Gerbeau J-F. Sequential parameter estimation for fluid–structure problems: Application to hemodynamics. International Journal for Numerical Methods in Biomedical Engineering 28:434–455, 2012. - PubMed
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