Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun;35(3):561-580.
doi: 10.1007/s12264-018-0323-6. Epub 2019 Jan 3.

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

Chao Luo  1   2   3 , Junyan Liu  4 , Xu Wang  1   2 , Xiaoyuan Mao  1   2 , Honghao Zhou  1   2   5 , Zhaoqian Liu  6   7   8
Affiliations
Review

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

Chao Luo et al. Neurosci Bull. 2019 Jun.

Abstract

Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that > 25 single-nucleotide polymorphisms in 19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not been included in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population, genome-wide association studies and multiple-center, standard, unified, and large samples are needed.

Keywords: Antipsychotic; Pharmacogenetic; Schizophrenia; Single nucleotide polymorphism; Weight gain.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Possible factors associated with antipsychotic-induced weight gain (AIWG).
Fig. 2
Fig. 2
Literature search strategy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Luan Z, Lu T, Ruan Y, Yue W, Zhang D. The human MSI2 gene is associated with schizophrenia in the Chinese Han population. Neurosci Bull. 2016;32:239–245. - PMC - PubMed
    1. Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, et al. Global epidemiology and burden of schizophrenia: Findings from the Global Burden of Disease Study 2016. Schizophr Bull. 2018;44:1195–1203. - PMC - PubMed
    1. Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, et al. Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register. Biol Psychiatry. 2017;83:492–498. - PubMed
    1. Bai Z, Wang G, Cai S, Ding X, Liu W, Huang D, et al. Efficacy, acceptability and tolerability of 8 atypical antipsychotics in Chinese patients with acute schizophrenia: A network meta-analysis. Schizophr Res. 2017;185:73–79. - PubMed
    1. Fonseka TM, Muller DJ, Kennedy SH. Inflammatory cytokines and antipsychotic-induced weight gain: review and clinical implications. Mol Neuropsychiatry. 2016;2:1–14. - PMC - PubMed

LinkOut - more resources