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Comment
. 2019 Jan 3;24(1):5-6.
doi: 10.1016/j.stem.2018.12.007.

The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation

Steven M Chan  1
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The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation

Steven M Chan. Cell Stem Cell. .
Free article

Abstract

Identification of key stemness regulators is critical for developing more effective therapies against acute myeloid leukemia stem cells (LSCs). In this issue of Cell Stem Cell, Park et al. (2019) report that IKZF2, a member of the Ikaros family of transcription factors, drives self-renewal and suppresses differentiation in LSCs through modulation of chromatin accessibility.

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  • IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.
    Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG. Park SM, et al. Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7. doi: 10.1016/j.stem.2018.10.016. Epub 2018 Nov 21. Cell Stem Cell. 2019. PMID: 30472158 Free PMC article.

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