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. 2019 Jan 3;24(1):7-8.
doi: 10.1016/j.stem.2018.12.005.

Venetolax with Azacitidine Drains Fuel from AML Stem Cells

Daisuke Nakada  1
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Venetolax with Azacitidine Drains Fuel from AML Stem Cells

Daisuke Nakada. Cell Stem Cell. .
Free article

Abstract

In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cycle, and depleted ATP in leukemia stem cells.

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