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Review
. 2019 Feb;15(2):67-68.
doi: 10.1038/s41584-018-0153-y.

Overcoming natural Wnt inhibition to optimize therapy

Affiliations
Review

Overcoming natural Wnt inhibition to optimize therapy

Natalie A Sims. Nat Rev Rheumatol. 2019 Feb.
No abstract available

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References

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    1. Holdsworth, G. et al. Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists. Bone 107, 93–103 (2018). - DOI
    1. Witcher, P. C. et al. Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition. JCI Insight 3, 98673 (2018). - DOI
    1. Luther, J. et al. Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. Sci. Transl Med. 10, eaau7137 (2018). - DOI
    1. Weske, S. et al. Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat. Med. 24, 667–678 (2018). - DOI

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