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. 2019 Feb;392(2):159-164.
doi: 10.1007/s00210-018-01603-0. Epub 2019 Jan 4.

All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats

Cem Yucel  1 , Elcin Erdogan Yucel  2 , Fatma Demet Arslan  3 , Sumeyye Ekmekci  4 , Erdem Kisa  5 , Volkan Ulker  5 , Murat Ucar  5 , Yusuf Ozlem Ilbey  5 , Orcun Celik  5 , Banu Isbilen Basok  3 , Zafer Kozacioglu  5
Affiliations

All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats

Cem Yucel et al. Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb.

Abstract

The aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1 ml/kg saline intra-peritoneally (IP) during 10 days. The rats in the ATRA group were injected a single dose of ATRA during 10 days. The rats in the ATRA+CP group were injected a single dose of CP on the fourth day of the 10 days of ATRA treatment. The rats in the CP group were injected a single dose of CP on the fourth day of 10 days without administering a treatment. After treatment, the groups were compared with regard to total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels in renal tissue and renal histopathology. The serum creatinine and urea values were statistically significantly higher in the CP group compared to the other groups. The serum creatinine and urea values were statistically significantly lower in the ATRA+CP group when compared to the CP group. Although the TOS and OSI levels were found to be lower in the ATRA+CP group compared to the CP group, the difference was not statistically significant. Administration of ATRA together with CP was observed to reduce the histopathologic destruction in the kidney and lead to mild tubular degeneration, vacuolization, and necrosis (57.1% grade 1; 28.6% grade2, and 14.3% grade 3 necrosis). The results of the present study have revealed that ATRA administration ameliorates CP-induced nephrotoxicity; however, further studies are required to identify this issue before clinical application.

Keywords: All-trans retinoic acid; Cisplatin; Nephrotoxicity.

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