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. 2019 Apr;276(4):1127-1133.
doi: 10.1007/s00405-018-5257-0. Epub 2019 Jan 4.

Elective neck treatment during salvage (pharyngo) laryngectomy

Simone E Bernard  1 , Marjan H Wieringa  2 , Cees A Meeuwis  2 , Robert J Baatenburg de Jong  2 , Aniel Sewnaik  2
Affiliations

Elective neck treatment during salvage (pharyngo) laryngectomy

Simone E Bernard et al. Eur Arch Otorhinolaryngol. 2019 Apr.

Abstract

Purpose: This study aimed at determining the importance of an elective neck dissection (END) in case of a cN0 laryngeal or hypopharyngeal carcinoma after (chemo) radiation.

Methods: Retrospective review was made of patients treated in a single tertiary center between 2002 and 2014. Influence of an END in case of a cN0 salvage laryngectomy on complications, recurrence-free survival and disease-specific survival was assessed.

Inclusion criteria: squamous cell carcinoma and cN0 neck.

Exclusion criteria: second primary tumor in the head and neck, a total laryngectomy because of a dysfunctional larynx, or a previously performed neck dissection.

Results: Of the 86 included patients, 27 (31%) underwent an END, of which 1 had occult metastasis (4%). Of the remaining 59 patients (69%) without an END, 3 developed a regional recurrence (5%). The overall survival was significantly higher for patients who had an END (p = 0.037). The incidence of complications was not significantly different between the two groups.

Conclusions: In light of the limited complications of an END and the poor prognosis of regional recurrence after previous (chemo)radiotherapy and a (pharyngo)laryngectomy, we advise consideration of an END at the time of a salvage laryngectomy.

Keywords: Head and neck cancer; Neck dissection; Occult metastasis; Salvage laryngectomy; Squamous cell carcinoma.

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