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. 2019 Jan 5;19(1):9.
doi: 10.1186/s12879-018-3633-4.

Mortality in hospitalized patients with tuberculous meningitis

Jaime Soria  1   2 , Tatiana Metcalf  3   2 , Nicanor Mori  4   2 , Renee E Newby  5   6   7 , Silvia M Montano  4 , Luz Huaroto  1   8 , Eduardo Ticona  1   8 , Joseph R Zunt  9
Affiliations

Mortality in hospitalized patients with tuberculous meningitis

Jaime Soria et al. BMC Infect Dis. .

Abstract

Background: To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality.

Methods: Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality.

Results: Of 263 patients, the median age was 35 years, 72.6% were men, 38% were positive for HIV upon admission, 24% had prior TB infections and 2.3% had prior MDR-TB infections. In-hospital mortality was 30.4% of all study patients with a final diagnosis of TBM. When multivariable analysis was applied, significant associations with in-hospital mortality were seen among patients with HIV (RR 2.06; Confidence Interval 95% (95% CI) 1.44-2.94), BMRC II (RR 1.78; 95% CI 1.07-2.97), BMRC III (RR 3.11; 95% CI 1.78-5.45) and positive CSF cultures (RR 1.95; 95% CI 1.39-2.74).

Conclusions: In-hospital mortality is higher among patients with HIV infections, age over 40 years, positive CSF TB culture and BMRC stage II or III.

Keywords: HIV; Meningitis; Tuberculosis.

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Conflict of interest statement

Ethics approval and consent to participate

The study protocol was approved by the ethics committee of Hospital Nacional Dos de Mayo and the IRB committee of the University of Washington. Data were collected directly from patient charts in this study, a common process in Peru, and need for consent was waived by both the in-country review board, OFICIO N° 043–2015-CEIB-AI-OACDI-HNDM Comité de Etica en Investigación Biomedica Hospital Nacional Dos de Mayo, and the University of Washington institutional review board.

Consent for publication

Not applicable.

Competing interests

The authors declare that there are no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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