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Review
. 2018 Nov 1:7:1732.
doi: 10.12688/f1000research.16521.2. eCollection 2018.

Research and development of new tuberculosis vaccines: a review

Lewis K Schrager  1 , Rebecca C Harris  2 , Johan Vekemans  3
Affiliations
Review

Research and development of new tuberculosis vaccines: a review

Lewis K Schrager et al. F1000Res. .

Abstract

Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and new Mtb infection are an essential component of the strategy to combat the TB epidemic. Accordingly, the WHO considers the development of new TB vaccines a major public health priority. In October 2017, the WHO convened a consultation with global leaders in the TB vaccine development field to emphasize the WHO commitment to this effort and to facilitate creative approaches to the discovery and development of TB vaccine candidates. This review summarizes the presentations at this consultation, updated with scientific literature references, and includes discussions of the public health need for a TB vaccine; the status of efforts to develop vaccines to replace or potentiate BCG in infants and develop new TB vaccines for adolescents and adults; strategies being employed to diversify vaccine platforms; and new animal models being developed to facilitate TB vaccine development. A perspective on the status of these efforts from the major funders and organizational contributors also is included. This presentation highlights the extraordinary progress being made to develop new TB vaccines and provided a clear picture of the exciting development pathways that are being explored.

Keywords: Mycobacterium tuberculosis; Tuberculosis; immunization; vaccines.

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Conflict of interest statement

No competing interests were disclosed.

References

    1. Organisation mondiale de la santé: Global tuberculosis report 2017.2017. Reference Source
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    1. Andrews JR, Noubary F, Walensky RP, et al. : Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis. Clin Infect Dis. 2012;54(6):784–91. 10.1093/cid/cir951 - DOI - PMC - PubMed
    1. Voss G, Casimiro D, Neyrolles O, et al. : Progress and challenges in TB vaccine development [version 1; referees: 2 approved]. F1000Res. 2018;7:199. 10.12688/f1000research.13588.1 - DOI - PMC - PubMed
    1. Schrager LK, Chandrasekaran P, Fritzell BH, et al. : WHO preferred product characteristics for new vaccines against tuberculosis. Lancet Infect Dis. 2018;18(8):828–9. 10.1016/S1473-3099(18)30421-3 - DOI - PubMed

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