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Comment
. 2017 Feb;6(Suppl 1):S83-S86.
doi: 10.21037/tcr.2017.02.35.

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao  1
Affiliations
Comment

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao. Transl Cancer Res. 2017 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
XPO1, also known as CRM1, as a novel therapeutic target for cancers. XPO1/CRM1 is overexpressed in different cancers. XPO1/CRM1 regulates various cancer-related proteins (cargoes). XPO1/CRM1 exports its cargoes through Ran in establishing the directionality of transport across the NPC. XPO1/CRM1 can be targeted by natural or synthetic inhibitors. XPO1, exportin 1; CRM1, chromosome region maintenance 1; NPC, nuclear pore complex.
See this image and copyright information in PMC

Comment on

  • XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
    Kim J, McMillan E, Kim HS, Venkateswaran N, Makkar G, Rodriguez-Canales J, Villalobos P, Neggers JE, Mendiratta S, Wei S, Landesman Y, Senapedis W, Baloglu E, Chow CB, Frink RE, Gao B, Roth M, Minna JD, Daelemans D, Wistuba II, Posner BA, Scaglioni PP, White MA. Kim J, et al. Nature. 2016 Oct 6;538(7623):114-117. doi: 10.1038/nature19771. Epub 2016 Sep 28. Nature. 2016. PMID: 27680702 Free PMC article.

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