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Comment
. 2017 May;6(Suppl 3):S578-S584.
doi: 10.21037/tcr.2017.05.05.

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M Selwan  1 , Aimee L Edinger  1
Affiliations
Comment

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M Selwan et al. Transl Cancer Res. 2017 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Differential acquisition of BCAAs in KP NSCLC and KP−/−C PDAC as described by Mayers et al. (16). Relative to normal tissue, SLC7A5 and BCAT1 were over-expressed in NSCLC but not PDAC; BCAT2 protein levels increased in both NSCLC and PDAC. BCKDH was inactivated by phosphorylation in NSCLC while in PDAC BCKDH total protein was greatly reduced. Isotopic labeling studies indicated that carbon from circulating BCAAs ended up in protein and BCKAs in NSCLC to a greater extent than in PDAC. Nitrogen from dietary leucine was used for BCAT-dependent nucleotide synthesis in NSCLC. BSA degradation in the lysosome was increased in isolated PDAC cells relative to NSCLC cells suggesting that PDAC cells may rely on macropinocytosis to compensate for reduced import of extracellular BCAAs through SLC7A5. BCAA, branched chain amino acid; NSCLC, non-small cell lung cancer; PDAC, pancreatic ductal adenocarcinoma; BCKDHA, branched chain keto acid dehydrogenase El alpha; BCAT, branched chain amino acid transferase.
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References

    1. Kim SM, Roy SG, Chen B, et al. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 2016;126:4088–102. - PMC - PubMed
    1. Denicola GM, Cantley LC. Cancer’s fuel choice: new flavors for a picky eater. Mol Cell 2015;60:514–23. - PMC - PubMed
    1. Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab 2016;23:27–47. - PMC - PubMed
    1. Selwan EM, Finicle BT, Kim SM, et al. Attacking the supply wagons to starve cancer cells to death. FEBS Lett 2016;590:885–907. - PMC - PubMed
    1. Röhrig F, Schulze A. The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer 2016;16:732–49. - PubMed