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Comment
. 2017 Aug;6(Suppl 6):S949-S952.
doi: 10.21037/tcr.2017.06.07.

New incriminating evidence against IGF2

Wen Ding  1   2 , Lina A Shehadeh  2   3   4
Affiliations
Comment

New incriminating evidence against IGF2

Wen Ding et al. Transl Cancer Res. 2017 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic diagram summarizing the regulatory role of the Id1/IGF2/VEGF/VEGFR pathway in esophageal squamous cell carcinoma (ESCC) progression. In the tumor microenvironment, IGF2 secreted by Id1-expressing cancer cells activates adjacent fibroblasts to become αSMA+ myofibroblasts, and to reduce expression of p53 causing reduction in miR-29c expression and subsequent de-repression of VEGF. In the tumor macro environment, VEGF secreted from the activated fibroblasts travels through the blood to the bone marrow instigating VEGFR+ bone marrow cells to migrate to the lung where CXCL5 expression attracts the invading cancer cells.
See this image and copyright information in PMC

Comment on

References

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