Tumor inactivation of E-cadherin: a new tool for breast cancer treatment?

Giovanni Corso^{1

2}, Bernardo Bonanni³, Paolo Veronesi^{1

2}

Affiliations

¹ Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy.
² Faculty of Medicine, University of Milan, Italy.
³ Division of Cancer Prevention and Genetics, European Institute of Oncology IRCCS, Milan, Italy.

Editorial

Giovanni Corso et al. Ann Transl Med. 2018 Nov.

. 2018 Nov;6(Suppl 1):S6.

doi: 10.21037/atm.2018.08.45.

Giovanni Corso^{1

2}, Bernardo Bonanni³, Paolo Veronesi^{1

2}

¹ Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy.
² Faculty of Medicine, University of Milan, Italy.
³ Division of Cancer Prevention and Genetics, European Institute of Oncology IRCCS, Milan, Italy.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM, Schmidt MK, Milne RL, Hardisson D, Benitez J, Blomqvist C, Bolla MK, Brenner H, Chang-Claude J, Cora R, Couch FJ, Cuk K, Devilee P, Easton DF, Eccles DM, Eilber U, Hartikainen JM, Heikkilä P, Holleczek B, Hooning MJ, Jones M, Keeman R, Mannermaa A, Martens JWM, Muranen TA, Nevanlinna H, Olson JE, Orr N, Perez JIA, Pharoah PDP, Ruddy KJ, Saum KU, Schoemaker MJ, Seynaeve C, Sironen R, Smit VTHBM, Swerdlow AJ, Tengström M, Thomas AS, Timmermans AM, Tollenaar RAEM, Troester MA, van Asperen CJ, van Deurzen CHM, Van Leeuwen FF, Van't Veer LJ, García-Closas M, Figueroa JD. Horne HN, et al. Sci Rep. 2018 Apr 26;8(1):6574. doi: 10.1038/s41598-018-23733-4. Sci Rep. 2018. PMID: 29700408 Free PMC article.

1. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 1993;5:806-11. 10.1016/0955-0674(93)90029-P - DOI - PubMed
1. Christofori G, Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999;24:73-6. 10.1016/S0968-0004(98)01343-7 - DOI - PubMed
1. Van Aken E, De Wever O, Correia da Rocha AS, et al. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 2001;439:725-51. 10.1007/s004280100516 - DOI - PubMed
1. Wasif N, Maggard MA, Ko CY, et al. Invasive lobular vs. ductal breast cancer: a stage-matched comparison of outcomes. Ann Surg Oncol 2010;17:1862-9. 10.1245/s10434-010-0953-z - DOI - PubMed
1. Horne HN, Oh H, Sherman ME, et al. E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. Sci Rep 2018;8:6574. 10.1038/s41598-018-23733-4 - DOI - PMC - PubMed