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Editorial
. 2018 Nov;6(Suppl 1):S63.
doi: 10.21037/atm.2018.10.34.

Microbial marauders: pancreatic microbiota and its impact on carcinogenesis

Ryan M Thomas  1 , Maria Zajac-Kaye  2
Affiliations
Editorial

Microbial marauders: pancreatic microbiota and its impact on carcinogenesis

Ryan M Thomas et al. Ann Transl Med. 2018 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Proposed mechanism of microbiota-mediated pancreatic carcinogenesis: elements of the intestinal microbiota colonize the pancreas which mediate an immune tolerant phenotype to PDAC via upregulation of MDSCs and M2 macrophage polarization. This leads to inhibition of cytotoxic CD8+ and CD4+ Th1 cells and PDAC progression. Microbiota depletion in host animals resulted in an upregulation of M1 macrophages with subsequent activation of cytotoxic CD8+ and CD4+ Th1 cells. Furthermore, these cells exhibited increased expression of the PD1 receptor that when inhibited resulted in PDAC regression. PDAC, pancreatic ductal adenocarcinoma; MDSC, myeloid derived suppressor cell.
See this image and copyright information in PMC

Comment on

  • The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.
    Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, Werba G, Zhang K, Guo Y, Li Q, Akkad N, Lall S, Wadowski B, Gutierrez J, Kochen Rossi JA, Herzog JW, Diskin B, Torres-Hernandez A, Leinwand J, Wang W, Taunk PS, Savadkar S, Janal M, Saxena A, Li X, Cohen D, Sartor RB, Saxena D, Miller G. Pushalkar S, et al. Cancer Discov. 2018 Apr;8(4):403-416. doi: 10.1158/2159-8290.CD-17-1134. Epub 2018 Mar 22. Cancer Discov. 2018. PMID: 29567829 Free PMC article.

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