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Meta-Analysis
. 2019 May;75(5):603-607.
doi: 10.1007/s00228-018-02617-6. Epub 2019 Jan 6.

Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials

Paul Vanderkam  1   2 , Clara Blanchard  3 , Florian Naudet  4 , Denis Pouchain  5 , Helene Vaillant Roussel  6 , Marie Christine Perault-Pochat  7 , Nematollah Jaafari  8 , Rémy Boussageon  9
Affiliations
Free article
Meta-Analysis

Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials

Paul Vanderkam et al. Eur J Clin Pharmacol. 2019 May.
Free article

Abstract

Purpose: To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness).

Methods: Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo.

Results: Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness.

Conclusion: There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.

Keywords: Acetylleucine; Dizziness; Randomised controlled trial; Treatment outcome; Vertigo.

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