Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May;95(5):558-568.
doi: 10.1111/cge.13502. Epub 2019 Jan 22.

Long non-coding RNAs differential expression in breast cancer subtypes: What do we know?

Carolina Mathias  1 , Erika P Zambalde  1 , Philip Rask  2 , Daniela F Gradia  1 , Jaqueline C de Oliveira  1
Affiliations
Review

Long non-coding RNAs differential expression in breast cancer subtypes: What do we know?

Carolina Mathias et al. Clin Genet. 2019 May.

Abstract

Breast Cancer (BC) is the most commonly diagnosed cancer and is the leading cause of cancer deaths in women. BC is a heterogeneous disease with different clinical and genetic features. According to immunohistochemical markers, BC is subdivided into four main subtypes: luminal A, luminal B, ERBB2 positive and triple negative. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides and deregulated lncRNAs are associated with human diseases, including BC. In order to improve BC molecular classification, non-coding RNAs (ncRNAs), including lncRNAs, have been used. In this review, we focus on lncRNAs with differential expression in BC subtypes and how these RNAs may act to contribute to BC heterogeneity. We also emphasize the potential of these lncRNAs as biomarkers.

Keywords: ER positive; breast cancer; breast cancer subtypes; lncRNA.

PubMed Disclaimer