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. 2018 Dec;35(6):614-619.
doi: 10.5114/ada.2018.77613. Epub 2018 Nov 13.

The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma

Karolina Wodok-Wieczorek  1 , Natalia Salwowska  2 , Ewa Syguła  1 , Aleksandra Wodok  3 , Dominika Wcisło-Dziadecka  4 , Katarzyna Bebenek  3 , Beata Bergler-Czop  2 , Ligia Brzezińska-Wcisło  2
Affiliations

The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma

Karolina Wodok-Wieczorek et al. Postepy Dermatol Alergol. 2018 Dec.

Abstract

Introduction: Scleroderma is a chronic connective tissue disease resulting in fibrosis.

Aim: The aim of the study was to determine the connection between sE-selectin and sIL-2R and the severity of skin lesions in various subtypes of LoS. Evaluation of disease severity, the location of skin lesions, the duration of symptoms and disease activity were assessed in relation to the three different LoS subtypes in patients with localized scleroderma.

Material and methods: The study included 42 patients with localized scleroderma and the control group consisted of 41 healthy subjects. All patients in the LoS study group had a confirmed diagnosis via skin biopsy and underwent serology testing for sE-selectin and sIL-2R concentrations by enzyme-linked immunosorbent assay (ELISA).

Results: Significantly higher levels of sE-selectin and sIL-2R were observed in the LoS study group when compared with the control group (p < 0.001). The analysis showed a result close to statistical significance (p = 0.058) between sE-selectin concentration during the time of active disease in the LoS study group. The highest concentrations of sE-selectin and sIL-2R were observed in patients with the generalized subtype of LoS. A positive, statistically significant, curvilinear relationship was shown amid the modified Localized Skin Severity Index (mLoSSI) and sE-selectin and sIL-2R concentrations in the LoS study group.

Conclusions: Concentrations of the circulating form of sE-selectin appear to be an adequate marker of the endothelial function, positively correlating with the severity of the disease. The proven correlation of sIL-2R concentrations with the severity of the disease indicates that it is a valuable prognostic factor for predicting the impending course of the disease.

Keywords: E-selectin; connective tissue disease; interleukin-2 receptors; localized scleroderma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Relationship between sE-selectin (A) and sIL-2R (B) concentrations and disease activity (mLoSSI) in patients with scleroderma
See this image and copyright information in PMC

References

    1. Chung L, Lin J, Furst DE, Fiorentino D. Systemic and localized scleroderma. Clin Dermatol. 2006;24:374–92. - PubMed
    1. Fett N, Werth VP. Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol. 2011;64:217–28. - PubMed
    1. Dunne JV, van Eeden SF, Keen KJ. L-selectin and skin damage in systemic sclerosis. PLoS One. 2012;7:e44814. - PMC - PubMed
    1. Iversen LV, Ostergaard O, Ullman S, et al. Circulating microparticles and plasma levels of soluble e- and p-selectins in patients with systemic sclerosis. Scand J Rheumatol. 2013;42:473–82. - PubMed
    1. Hasegawa M, Asano Y, Endo H, et al. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. PLoS One. 2014;9:e88150. - PMC - PubMed