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Review
. 2018 Dec 20:9:2987.
doi: 10.3389/fimmu.2018.02987. eCollection 2018.

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act

Vandana Kalia  1   2 , Surojit Sarkar  1   2   3   4
Affiliations
Review

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act

Vandana Kalia et al. Front Immunol. .

Abstract

Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology-signaling through distinct pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum of physiological outcomes such as cell survival, proliferation, and effector differentiation. In addition to driving effector differentiation, IL-2 signals are also critical for formation of long-lived CD8 T cell memory. This review discusses a model of rheostatic control of CD8 T cell effector and memory differentiation by IL-2, wherein the timing, duration, dose, and source of IL-2 signals are considered in fine-tuning the balance of key transcriptional regulators of cell fate.

Keywords: CD8 T cell memory; IL-2; autocrine; metabolism; terminal effectors; transcription factors.

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Figures

Figure 1
Figure 1
Regulation of key intracellular signaling, transcriptional, and metabolic mediators of terminal effector vs. long-lived polyfunctional memory CD8 T cell fates are presented in the context of differential levels of IL-2 signals.
See this image and copyright information in PMC

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