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Review
. 1988 May;23(5):449-67.
doi: 10.3109/10826088809039211.

Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo

M H Orzack  1 , L Friedman, E Dessain, M Bird, B Beake, J McEachern, J O Cole
Affiliations
Review

Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo

M H Orzack et al. Int J Addict. 1988 May.

Abstract

Subjective effects of two benzodiazepines--alprazolam and lorazepam--were compared with two drugs of known abuse potential--diazepam and methaqualone--and placebo. This double-blind, crossover trial tested 30 casual recreational sedative users in a seminaturalistic setting. Methaqualone was more euphoriant and less sedative than the benzodiazepines. Diazepam and lorazepam were more euphoriant than placebo; alprazolam's euphoriant effect did not differ from these treatments. On other measures of abuse liability the benzodiazepines rated similarly, diazepam rating highest.

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