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. 2018 Dec 13:8:596.
doi: 10.3389/fonc.2018.00596. eCollection 2018.

MiRNA Polymorphisms and Cancer Prognosis: A Systematic Review and Meta-Analysis

Han-Xi Ding  1 , Zhi Lv  1 , Yuan Yuan  1 , Qian Xu  1
Affiliations

MiRNA Polymorphisms and Cancer Prognosis: A Systematic Review and Meta-Analysis

Han-Xi Ding et al. Front Oncol. .

Abstract

Background: Accumulating studies have focused on the relationship between miRNAs polymorphisms and cancer prognosis. However, the results are conflicting and unconvincing. This systematic review and meta-analysis was conducted to explore the relationship between miRNAs polymorphisms and cancer prognosis, aiming to seek for markers with cancer prognostic function. Methods: Hazard ratio of overall survival, disease-free survival (DFS) and recurrence-free survival were calculated to evaluate the association between miRNAs polymorphisms and cancer prognosis by using Stata software 11.0. Results: We systematically reviewed the association of 17 miRNAs SNPs with cancer prognosis including 24,721 samples. It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS. Conclusions: In summary, let-7i rs10877887, miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-423 rs6505162, miR-499 rs4919510, miR-149 rs2292832, miR-146 rs2910164, and miR-196a2 rs11614913 might serve as potential biomarkers for cancer prognosis.

Keywords: cancers; meta-analysis; miRNAs; single nucleotide polymorphisms; systematic review.

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Flow diagram of the study selection process.
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