An Electric Take on Neural Fate and Cortical Development
- PMID: 30620896
- DOI: 10.1016/j.devcel.2018.12.014
An Electric Take on Neural Fate and Cortical Development
Abstract
Membrane potential is well-studied in neuronal physiology, but its role in brain development and cell fate determination is less well understood. In two recent studies, bioelectric properties of progenitors and migrating neurons are shown to be tightly regulated, and their disruption leads to abnormalities in fate determination and neuronal positioning.
Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.
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Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.Cell. 2018 Aug 23;174(5):1264-1276.e15. doi: 10.1016/j.cell.2018.06.036. Epub 2018 Jul 26. Cell. 2018. PMID: 30057116 Free PMC article.
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