Microglia: Picky Brain Eaters
- PMID: 30620901
- DOI: 10.1016/j.devcel.2018.12.013
Microglia: Picky Brain Eaters
Abstract
Many aspects of brain development, function, and repair depend on the interaction of neurons with brain immune cells, the microglia. By combining CLEM and SPIM microscopy, a recent study has challenged the current view that microglia can "eat" entire synapses, highlighting the incredible complexity of neuronal-microglial interactions in vivo.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.Nat Commun. 2018 Mar 26;9(1):1228. doi: 10.1038/s41467-018-03566-5. Nat Commun. 2018. PMID: 29581545 Free PMC article.
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