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Comment
. 2019 Jan 7;48(1):5-6.
doi: 10.1016/j.devcel.2018.12.012.

TRIMing Neural Connections with Ubiquitin

Denise J Montell  1
Affiliations
Comment

TRIMing Neural Connections with Ubiquitin

Denise J Montell. Dev Cell. .

Abstract

During evolution, ubiquitin ligases increased in number with increasing nervous system complexity. Recent work shows that proper brain development, cognitive ability, and social behavior in mice require the ubiquitin ligase TRIM67. The work illuminates how general regulators like ubiquitin promote specific functions such as nervous system wiring during development.

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References

    1. Boyer NP, Monkiewicz C, Menon S, Moy SS, and Gupton SL (2018). Mammalian TRIM67 functions in brain development and behavior. eNeuro 5, ENEURO.0186–18.2018. - PMC - PubMed
    1. Deshaies RJ, and Joazeiro CAP (2009). RING domain E3 ubiquitin ligases. Annu. Rev. Biochem 78, 399–434. - PubMed
    1. Hao JC, Adler CE, Mebane L, Gertler FB, Bargmann CI, and Tessier-Lavigne M (2010). The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Dev. Cell 18, 950–960. - PMC - PubMed
    1. Hedgecock EM, Culotti JG, and Hall DH (1990). The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61–85. - PubMed
    1. Menon S, Boyer NP, Winkle CC, McClain LM, Hanlin CC, Pandey D, Rothenfußer S, Taylor AM, and Gupton SL (2015). The E3 ubiquitin ligase TRIM9 is a filopodia off switch required for netrin-dependent axon guidance. Dev. Cell 35, 698–712. - PMC - PubMed