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. 2019 Jan 4;11(1):92.
doi: 10.3390/nu11010092.

Consumption of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity

Philippe Marteau  1   2 , Boris Le Nevé  3 , Laurent Quinquis  4 , Caroline Pichon  5 , Peter J Whorwell  6 , Denis Guyonnet  7
Affiliations

Consumption of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity

Philippe Marteau et al. Nutrients. .

Abstract

Background. Minor digestive symptoms are common and dietary approaches such as probiotic administration or fibre and fermentable carbohydrate intake adjustments are often recommended. A Fermented Milk Product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria has been shown to improve digestive symptoms after 4 weeks of consumption, but the speed of onset of this effect and its dependence on fibre intake or physical activity is unknown. To answer these questions, data from two previously published trials on FMP for minor digestive symptoms were combined. Methods. In total, 538 participants provided weekly assessments of bloating, abdominal pain/discomfort, flatulence, borborygmi/rumbling stomach from which a composite score was calculated. At baseline in one study (n = 336), dietary fibre consumption was recorded and physical activity classified as high, moderate or low. The speed of the FMP's effect was assessed by a repeated measure analysis of variance measuring the change from baseline for the composite score of digestive symptoms. Results. FMP consumption resulted in a significant decrease in the composite score of symptoms after only 2 weeks in both studies and the pooled data at week 1 (-0.35 [-0.69, 0.00]; p = 0.05), week 2 (-0.66 [-1.04, -0.27]; p < 0.001), week 3 (-0.49 [-0.89, -0.10]; p = 0.01) and week 4 (-0.46 [-0.88, -0.04]; p = 0.03). The interactions fibre intake-by-product group, physical activity-by-product group and time-by-product group were not statistically significant. Conclusion. FMP consumption leads to a rapid improvement in symptoms which is likely to encourage adherence to this dietary intervention. This effect is independent of dietary fibre and physical activity.

Keywords: Bifidobacterium lactis CNCM I-2494; diet; digestive symptoms; gastrointestinal discomfort; physical activity; probiotic.

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Conflict of interest statement

P.M. serves as a paid consultant to Danone, Biocodex and has served as a speaker for Danone, Biocodex, B.L.N., L.Q., C.P. are employees of Danone Nutricia Research, P.J.W. has served as a paid consultant to Danone, D.G. was an employee of Danone Nutricia Research when this work was performed and has no relevant conflict of interest to declare.

Figures

Figure 1
Figure 1
LS-Means differences and 95% confidence interval (CI) (FMP–Control) from Baseline of composite score of digestive symptoms by week (N = 535).
See this image and copyright information in PMC

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References

    1. L’Heureux-Bouron D., Legrain-Raspaud S., Carruthers H.R., Whorwell P.J. Minor digestive symptoms and their impact in the general population: A cluster analysis approach. Ther. Adv. Gastroenterol. 2018;11:1756284818768814. doi: 10.1177/1756284818768814. - DOI - PMC - PubMed
    1. Chang L., Di Lorenzo C., Farrugia G., Hamilton F.A., Mawe G.M., Pasricha P.J., Wiley J.W. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018;154:723–735. doi: 10.1053/j.gastro.2017.12.010. - DOI - PubMed
    1. Camilleri M., Boeckxstaens G. Dietary and pharmacological treatment of abdominal pain in IBS. Gut. 2017;66:966–974. doi: 10.1136/gutjnl-2016-313425. - DOI - PubMed
    1. Johannesson E., Ringström G., Abrahamsson H., Sadik R. Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects. World J. Gastroenterol. 2015;21:600–608. doi: 10.3748/wjg.v21.i2.600. - DOI - PMC - PubMed
    1. Hungin A.P.S., Mitchell C.R., Whorwell P., Mulligan C., Cole O., Agréus L., Fracasso P., Lionis C., Mendive J., Philippart de Foy J.M., et al. Systematic review: probiotics in the management of lower gastrointestinal symptoms—An updated evidence-based international consensus. Aliment. Pharmacol. Ther. 2018;47:1054–1070. doi: 10.1111/apt.14539. - DOI - PMC - PubMed