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Clinical Trial
. 1988 Nov;235(8):449-53.
doi: 10.1007/BF00314245.

Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis

R Mantegazza  1 , C Antozzi, D Peluchetti, A Sghirlanzoni, F Cornelio
Affiliations
Clinical Trial

Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis

R Mantegazza et al. J Neurol. 1988 Nov.

Abstract

Azathioprine (Aza) has been used alone or in combination with steroids for two groups of myasthenic patients. Positive responses were noted in 75% of patients on Aza alone and in 70% receiving the combined regimen. The clinical course of the two groups differed in terms of respiratory crisis and need for plasma exchange. With an appropriate Aza administration schedule side-effects were not a limiting factor to its use. Aza treatment induced a reduction in anti-AchR-antibody level that was correlated with clinical improvement and greatly decreased the need for steroids.

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