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. 2019 Jan 8;18(1):9.
doi: 10.1186/s12944-019-0958-y.

Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Jia Zheng  1 , Zhaoqing Sun  2 , Xingang Zhang  3 , Zhao Li  3 , Xiaofan Guo  3 , Yanxia Xie  1 , Yingxian Sun  4 , Liqiang Zheng  5
Affiliations

Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Jia Zheng et al. Lipids Health Dis. .

Abstract

Background: Studies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.

Methods: This study was a large-scale study with a median follow-up of 8.4 years. The hazard ratio (HR) and 95% Confidence interval (CI) of lipid variables for risk of incident stroke were analyzed by multivariable Cox proportional hazard models.

Results: During the follow-up, 502 new strokes (310 ischemic, 187 hemorrhagic, and 5 unclassified strokes) occurred among the 5099 hypertensive patients. Comparing with the lowest quarter, the HR of future ischemic stroke (IS) in the highest were 1.41(95%CI, 1.03-1.92) for TC, 1.60 (95%CI, 1.15-2.22) for TG, 1.03 (95%CI, 0.75-1.42) for HDL-C, 1.77 (95%CI, 1.29-2.44) for LDL-C, 1.42 (95%CI, 1.03-1.94) for non-HDL, 2.09 (95%CI, 1.45-3.00) for TC/HDL, 2.08 (95%CI, 1.46-2.96) for LDL/HDL, 1.86 (95%CI 1.33-2.60) for TG/HDL, respectively. No significant association was observed between lipid-related indicators and hemorrhagic stroke. The results of statistical differences showed that the correlation between LDL/HDL and the risk of ischemic stroke in non-traditional lipids was higher than that of other traditional lipids (P < 0.001), except for LDL (P = 0.056).

Conclusions: We didn't find that HDL was associated with the risk of stroke and all the lipid parameters were not associated with the risk of hemorrhagic stroke. LDL/HDL was associated with a higher risk of ischemic stroke than other lipids and should be considered for clinical diagnosis and future disease prevention.

Keywords: Hemorrhagic stroke; Ischemic stroke; Non-traditional lipids; Prospective study; Traditional lipids.

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Conflict of interest statement

Ethics approval and consent to participate

The Ethics Committee of China Medical University has approved the research plan and written informed consent has been formally obtained from all patients or their guardians.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Adjusted hazard ratios and 95% CIs for future all stroke of each lipid variables according to 1-SD increase. Hazard ratios were adjusted for age, sex, ethnicity, BMI, current smoking, heavy drinking, diabetes mellitus, SBP, DBP, and anti-hypertensive medications
Fig. 2
Fig. 2
Adjusted hazard ratios and 95% confidence intervals for future ischemic stroke of each lipid variables according to 1-SD increase. Hazard ratios were adjusted for age, sex, ethnicity, BMI, current smoking, heavy drinking, diabetes mellitus, SBP, DBP, and anti-hypertensive medications
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