Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 15;15(1):39-45.
doi: 10.5664/jcsm.7566.

Evaluation of Home Polysomnography Findings, Quality of Sleep, and Fatigue in Inflammatory Bowel Disease: A Case Series

Deise Lun Paixão  1 , Dalva Poyares  2   3 , Marta Sevilh de Paula  3 , Joselmo Willamy Duarte  1 , Paula Midor Castelo  4 , Orlando Ambrogini-Júnior  5 , Sender Jankie Miszputen  5 , Celina Tizuko Fujiyam Oshima  1   5 , Jair Ribeir Chagas  2 , Ana Paula Ribeir Paiotti  1   5
Affiliations

Evaluation of Home Polysomnography Findings, Quality of Sleep, and Fatigue in Inflammatory Bowel Disease: A Case Series

Deise Lun Paixão et al. J Clin Sleep Med. .

Abstract

Study objectives: The pathogenesis of inflammatory bowel disease (IBD) is not well understood, and sleep disorders may be potential triggers for IBD. Thus, an evaluation of the sleep characteristics, fatigue symptoms, and cytokine levels was performed in patients with IBD during periods of active disease and remission.

Methods: A total of 20 participants presenting with Crohn's disease or ulcerative colitis, with active disease (n = 7) or in remission (n = 13), underwent home polysomnography (H-PSG). Pittsburgh Sleep Quality Index (PSQI) and Modified Fatigue Impact Scale (MFIS) were applied, in addition to the evaluation of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNF-α) serum levels. Exploratory analysis, t test and Mann-Whitney U test were used.

Results: The mean sleep latency in patients with active disease was 133.07 minutes and 106.79 minutes in those in remission. The sleep efficiency and sleep fragmentation in patients with active disease and those in remission were 80.90% and 84.20% (median), and 76.36/min and 69.82/min (mean), respectively, although the H-PSG parameters did not differ between the groups. The PSQI scores indicated poor sleep quality (global score above 5) in all participants with IBD, and the participants with active disease presented more symptoms of fatigue (P = .032). IL-6 and TNF-α average levels were higher in the participants with disease remission, although with a larger dispersion of the data.

Conclusions: No significant difference in the H-PSG characteristics was observed between the patients with IBD with active disease and those in remission; however, the perception of the participants with IBD showed significant effect on the sleep quality and fatigue symptoms.

Keywords: fatigue; inflammatory bowel disease; interleukins; polysomnography; sleep disorders.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Results of the PSQI.
Total score of PSQI according to the groups and clinical condition (P > .05). CD = Crohn's disease, PSQI = Pittsburgh Sleep Quality Index, UC = ulcerative colitis.
Figure 2
Figure 2. Results of the MFIS.
Total score of MFIS questionnaire according to the clinical condition (* t = 1.975; P = .032, one-tailed t test; power = 60%). MFIS = Modified Fatigue Impact Scale.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Burisch J, Munkholm P. The epidemiology of inflammatory bowel disease. Scand J Gastroenterol. 2015;50(8):942–951. - PubMed
    1. Delmondes LM, Nunes MO, Azevedo AR, Oliveira MM, Coelho LE, Torres-Neto JD. Clinical and sociodemographic aspects of inflammatory bowel disease patients. Gastroenterology Res. 2015;8(3–4):207–215. - PMC - PubMed
    1. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1785–1794. - PubMed
    1. de S B Fróes R, Carvalho ATP, de V Carneiro AJ, et al. The socio-economic impact of work disability due to inflammatory bowel disease in Brazil. Eur J Health Econ. 2018;19(3):463–470. - PubMed
    1. da Silva BC, Lyra AC, Mendes CM, et al. The demographic and clinical characteristics of ulcerative colitis in a northeast Brazilian population. Biomed Res Int. 2015;2015:359130. - PMC - PubMed

Publication types