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Review
. 2018 Jan-Mar;44(1):19-22.
doi: 10.12865/CHSJ.44.01.03. Epub 2018 Jan 6.

Histopathological Patterns of Microinvasion in Ovarian Serous Borderline Tumors

A E Cîrstea  1 , A E Stepan  2 , R E Zăvoi  3 , C E Simionescu  2
Affiliations
Review

Histopathological Patterns of Microinvasion in Ovarian Serous Borderline Tumors

A E Cîrstea et al. Curr Health Sci J. 2018 Jan-Mar.

Abstract

Stromal microinvasion in ovarian serous borderline tumors can take various aspects, some of which are difficult to identify. Thus, the identification of stromal microinvasion is relatively simple for typical intracystic papillary proliferations such as serous borderline tumors, but may be difficult for tumors with glandular component. The study analyzed 14 cases of ovarian serous borderline tumors diagnosed in patients with mean age of 47,1 years. Histopathologically all tumors corresponded to typical forms in which we identified only two cases of stromal microinvasion. In one case, microinvasion was of eosinophilic type, and in the other case was observed a glandular and micropapillary pattern, being associated with the noninvasive peritoneal implants.

Keywords: microinvasion; serous borderline tumors.

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Figures

Figure 1
Figure 1
Microinvasion with eosinophilic pattern, HE staining, x40
Figure 2
Figure 2
Microinvasion with micropapillary pattern, HE staining, x100
Figure 3
Figure 3
Microinvasion with glandular pattern, HE staining, x40
Figure 4
Figure 4
Noninvasive peritoneal implant, HE staining, x40
See this image and copyright information in PMC

References

    1. Seidman JD, Bell DA, Crum CP, Gilks CB, Kurman RJ, Levine DA, Lonacre TA, Pasini B, Riva C, Sherman ME, Shih IM, Singer G, Soslow R, Vang R. Tumours of the ovary: Epithelial tumours – Serous tumours . In: Kurman R.J., Carcangiu M.L., Harrington C.S., Young R.H., editors. WHO Classification of tumors of female reproductive organs. 2014. pp. 17–18.
    1. Bell DA, Scully RE. Ovarian serous borderline tumors with stromal microinvasion: a report of 21 cases. Hum Pathol. 1990;4(21):397–403. - PubMed
    1. Tavassoli FA. Serous tumor of low malignant potential with early stromal invasion (serous LMP with microinvasion) Mod Pathol. 1988;6(1):407–414. - PubMed
    1. Kennedy AW, Hart WR. Ovarian papillary serous tumors of low malignant potential (serous borderline tumors). A long-term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma. Cancer. 1996;2(78):278–286. - PubMed
    1. McKenney JK, Balzer BL, Longacre TA. Patterns of stromal invasion in ovarian serous tumors of low malignant potential (borderline tumors): a reevaluation of the concept of stromal microinvasion. Am J Surg Pathol. 2006;10(30):1209–1221. - PubMed

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