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. 2018 Mar 24;1(4):e34.
doi: 10.1002/hsr2.34. eCollection 2018 Apr.

Effects of bovine lipid extract surfactant administration in preterm infants treated for respiratory distress syndrome

Elizabeth Stockley  1 , Ronald Valotaire  1 , Michael Miller  1 , Orlando da Silva  1
Affiliations

Effects of bovine lipid extract surfactant administration in preterm infants treated for respiratory distress syndrome

Elizabeth Stockley et al. Health Sci Rep. .

Abstract

Aim: To review the initial effectiveness of bovine lipid extract surfactant (BLES) for the treatment of respiratory distress syndrome in preterm infants.

Methods and results: A retrospective review of data collected from infants born <37-week gestation with respiratory distress syndrome treated with BLES between February 1, 2015 and March 1, 2016. Data were analyzed to determine the timing of initial dose, the length of time to wean the fraction of inspired oxygen (FiO2) concentration to 0.21 following initial dose, and the number of repeated doses given during hospital admission. Infants were subgrouped by gestational age stratum, 230 to 276 weeks (group 1), 280 to 316 weeks (group 2), and 320 to 366 weeks (group 3). Ninety-eight infants received the surfactant during the study period. After applying exclusion criteria, 77 infants were analyzed. Mean (SD) gestational age was 28 (4) weeks, and mean (SD) birth weight was 1250 (602) g. Initial dose of BLES was given at a median (interquartile range) time of 29 (19-43) minutes in group 1, 150 (20-615) minutes in group 2, and 990 (53-2025) minutes in group 3. Median (interquartile range) length of time to wean the FiO2 concentration to 0.21 was 14 (5-56) minutes, 10 (5-53) minutes, and 10 (5-38) minutes in groups 1, 2, and 3, respectively. Ten infants required repeated doses.

Conclusion: Given the rapid response of BLES in all the groups, careful monitoring of ventilator parameters is paramount to allow for rapid weaning and early extubation to avoid lung injury associated with mechanical ventilation.

Keywords: BLES; FiO2; RDS; preterm.

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Figures

Figure 1
Figure 1
Flow diagram of results. BLES, bovine lipid extract surfactant; IQR, interquartile range; SD, standard deviation
Figure 2
Figure 2
Response time of bovine lipid extract surfactant in all preterm infants
See this image and copyright information in PMC

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References

    1. Palta M, Weinstein MR, McGuiness G, Gabbert D, Brady W, Peters ME. A population study. Mortality and morbidity after availability of surfactant therapy. Newborn Lung Project. Arch Ped Adolesc Med J. 1994;148:1295‐1301. - PubMed
    1. Schwartz RM, Luby AM, Scanlon JW, Kellogg RJ. Effects of surfactant on morbidity, mortality and resource use in newborn infants weighing 500 to 1500 g. New England J Med. 1994;330(21):1476‐1480. - PubMed
    1. Ferrara TB, Hoekstra RE, Couser RJ, et al. Survival and follow‐up of infants born at 23 to 26 weeks gestational age: effects of surfactant therapy. J Pediatr. 1994;124(1):119‐124. - PubMed
    1. Corbert A, Bucciarelli R, Goldman S, Mammel M, Wold D, Long W. Decreased mortality among small premature infants treated at birth with a single dose of synthetic surfactant: a multicentre controlled trial. J Pediatr. 1991;119:455‐457. - PubMed
    1. Polin RA, Carlo WA. Committee on fetus and newborn. Surfactant replacement therapy for preterm and term neonates with respiratory distress. Am Academy Ped. 2014;133(1):156‐163. - PubMed

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